Inhibitory effect of thyroid hormones on pituitary cyclic AMP phosphodiesterase activity in vitro |
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| Authors: | Akio Nagasaka Hiroyoshi Hidaka Kunitaka Kataoka Katsumi Iwase Hifumi Nakagawa Akira Nakai Toshihiro Aono Takako Ohyama |
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| Institution: | (1) Department of Internal Medicine, Fujita-Gakuen University School of Medicine, 470-11 Toyoake, Aichi;(2) Surgery, Fujita-Gakuen University School of Medicine, 470-11 Toyoake, Aichi;(3) Department of Pharmacology, Mie University School of Medicine, 514 Tsu, Mie, Japan |
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| Abstract: | Thyroid hormones effectively inhibited partially purified cyclic AMP phosphodiesterase from the anterior and posterior lobes of bovine pituitary gland competitively with the substrate, but thyronine, diiodotyrosine, monoiodotyrosine, thyrotropin, thyrotropin releasing hormone, dexamethasone, and luteinizing hormone releasing hormone did not inhibit this enzyme activity.K
i values were found to be 1.0 and 2.5  M for thyroxine, and 8.0 and 13.5 M for triiodothyronine in the anterior and posterior lobes, respectively. |
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