Red cell genotyping and the future of pretransfusion testing |
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| Junhua Hu, YuShiang Lin, Rong Xia, Shuming Zhao, Xiaoning Wang, Huayou Zhou, Jiangcun Yang, Zhiwei Liu, Pu Xu, Changjiu Tang, Xiaoyu Zhou, Maohong Bian, Haiyan Wang, Chan Zhang, Xianjun Ma, Ying Xu, Yuanshuai Huang, Peiyuan Zhu, Bailing Zhang, Zhuning Mo, Wenting Wang, Dongxia Ren, Qiang Fu, Min Zhang, Wenjing Hu, Meng Li, Hongjun Yang, Qing Nian, Zhengcai Ao, Peng Zhang, Lei Yu, Jingyan Chang, Bing Sun, Jiwu Gong. Clinical practice of ABO blood group molecular analysis: Chinese expert consensus[J]. Blood&Genomics, 2023, 7(2): 77-85. DOI: 10.46701/BG.2023022023023 |
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| Authors: | Junhua Hu YuShiang Lin Rong Xia Shuming Zhao Xiaoning Wang Huayou Zhou Jiangcun Yang Zhiwei Liu Pu Xu Changjiu Tang Xiaoyu Zhou Maohong Bian Haiyan Wang Chan Zhang Xianjun Ma Ying Xu Yuanshuai Huang Peiyuan Zhu Bailing Zhang Zhuning Mo Wenting Wang Dongxia Ren Qiang Fu Min Zhang Wenjing Hu Meng Li Hongjun Yang Qing Nian Zhengcai Ao Peng Zhang Lei Yu Jingyan Chang Bing Sun Jiwu Gong |
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| Affiliation: | 1.Department of Blood Transfusion, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China;2.The First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi 710068, China;3.Department of Blood Transfusion, Huashan Hospital, Fudan University, Shanghai 200040, China;4.Department of Blood Transfusion, Guiqian International General Hospital, Guiyang, Guizhou 550018, China;5.Department of Blood Transfusion, the First Hospital of Jilin University, Changchun, Jilin 130021, China;6.Department of Transfusion Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China;7.Department of Transfusion Medicine, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi 710068, China;8.Department of Blood Transfusion, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310016, China;9.Department of Blood Transfusion, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China;10.Department of Blood Transfusion, Jiangxi Provincial People's Hospital, Nanchang, Jiangxi 330006, China;11.Department of Blood Transfusion, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China;12.Department of Blood Transfusion, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China;13.Department of Blood Transfusion, the Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, China;14.Department of Blood Transfusion, the First People's Hospital of Yunnan Province, the Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan 650032, China;15.Department of Blood Transfusion, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China;16.Department of Blood Transfusion, the First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan 610500, China;17.Department of Blood Transfusion, the Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China;18.Department of Transfusion Medicine, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210022, China;19.Department of Blood Transfusion, the Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330200, China;20.Department of Blood Transfusion, the People's Hospital of Guangxi Zhuang Autonomous Region, Guangxi Academy of Medical Sciences, Nanning, Guangxi 530021, China;21.Department of Blood Transfusion, the Second Affiliated Hospital of Air Force Medical University, Xi'an, Shaanxi 710038, China;22.Department of Blood Management, Nanjing Red Cross Blood Center, Nanjing, Jiangsu 210003, China;23.Department of Blood Transfusion, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu 210009, China;24.Department of Blood Transfusion, Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital, Nanjing, Jiangsu 210004, China;25.Department of Blood Transfusion, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu 210019, China;26.Department of Blood Transfusion, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, China;27.Department of Blood Transfusion, Sichuan Provincial People's Hospital, Sichuan Academy of Medical Sciences, Chengdu, Sichuan 610072, China;28.Department of Blood Transfusion, Chengdu Fifth People's Hospital, Chengdu, Sichuan 611130, China;29.Department of Blood Transfusion, Guiyang Maternal and Child Health Hospital, Guiyang, Guizhou 550003, China;30.Department of Blood Transfusion, the 63680 Military Hospital of People's Liberation Army, Jiangyin, Jiangsu 214431, China |
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| Abstract: | The ABO blood group, based on molecular biological detection technology, has the advantages of simple operation, high sensitivity, and standardized result interpretation, and is not affected by sample immunological characteristics. However, clinically, performance verification, clinical application scope, quality management, abnormal result processing, and other issues associated with the ABO blood group molecular detection technology are relatively complex, and there is a lack of unified norms and standards. Therefore, from the perspective of the whole process of ABO molecular biology detection, this study aims to provide standardized opinions on important links affecting the detection results, common problems encountered in the detection process, and the assessment and treatment of abnormal results. Finally, a Chinese expert consensus on molecular biological technology based on genotyping and sequencing detection was put forward, which standardizes the detection process, improves the accuracy of results, and promotes the development of technology and broader clinical application. |
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| Keywords: | ABO blood group molecular detection technology genotyping detection sequencing detection ABO allele |
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