Synchronized Growth In Human Epidermis Following Tape-Stripping: Its Implication For Cell Kinetic Studies |
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Authors: | J J Rijzewijk J B M Boezeman F W Bauer |
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Institution: | Department of Dermatology, University of Nijmegen, the Netherlands;Hoffman-La Roche, Busel, Switzerland |
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Abstract: | Abstract. A after stimulation A recent investigation of the hyperproliferative activity of human epidermis following sellotape stripping showed a wave of cell divisions with a maximal percentage of cells in mid-S phase at about 39 h after stripping. Here we present a study over the period of 52-76 h following stripping, showing a second wave of cell divisions with a maximal percentage of cells in mid-S at about 63 h. This indicates an average cell cycle time of about 23 h. Human epidermis after tape-stripping provides us with a useful model of synchronized growth, allowing us to study drug influences on cell kinetics accurately. |
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