Synthesis and SAR of aminoalkoxy-biaryl-4-carboxamides: novel and selective histamine H3 receptor antagonists |
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| Authors: | Faghih Ramin Dwight Wesley Pan Jia Bao Fox Gerard B Krueger Kathy M Esbenshade Timothy A McVey Jill M Marsh Kennan Bennani Youssef L Hancock Arthur A |
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| Institution: | Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park 60064-6123, USA. ramin.fagih@abbott.com |
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| Abstract: | Novel 4'-(NR1R2-1-yl)]-propoxy-biaryl-4-carboxamides were designed and synthesized. All compounds were tested for affinity at histamine H(3)receptors. Most compounds were highly potent and selective for human and rat H(3) receptors and selected examples such as A-349821 showed functional antagonism of H(3) receptors in vitro and in a mouse dipsogenia model. |
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