MicroRNA-26a-mediated regulation of interleukin-2 expression in transformed avian lymphocyte lines |
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Authors: | Hongtao Xu Yongxiu Yao Lorraine P Smith Venugopal Nair |
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Institution: | (1) Avian Oncogenic Virus Group, Avian Infectious Diseases Programme, Institute for Animal Health, RG20 7NN Compton, Berkshire, UK |
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Abstract: | Background Micro(mi)RNAs are a class of small non-coding RNAs that play critical roles in the induction of various cancers, including
lymphomas induced by oncogenic viruses. While some of the miRNAs are oncogenic, miRNAs such as miR-26a are consistently downregulated
in a number of cancers, demonstrating their potential tumor suppressor functions. Global miRNA expression profiles of a number
of virus-transformed avian lymphoma cell lines have shown downregulation of gga-miR-26a expression, irrespective of molecular
mechanisms of transformation or the viral aetiology. The neoplastic transformation of lymphocytes by many viruses accompanies
high levels of proliferative responses, mostly mediated through cytokines such as IL-2. Chicken IL-2 can modulate T-cell proliferation
and cytotoxicity in vitro and in vivo and dysregulation of IL-2 expression is observed in diseases such as leukaemia. |
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