Isolation of cell-free bacterial inclusion bodies |
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Authors: | Escarlata Rodríguez-Carmona Olivia Cano-Garrido Joaquin Seras-Franzoso Antonio Villaverde Elena García-Fruitós |
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Institution: | 1.Institut de Biotecnologia i de Biomedicina and Departament de Genètica i de Microbiologia,Universitat Autònoma de Barcelona,Barcelona,Spain;2.CIBER en Bioingeniería,Biomateriales y Nanomedicina (CIBER-BBN),Barcelona,Spain |
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Abstract: | Background Bacterial inclusion bodies are submicron protein clusters usually found in recombinant bacteria that have been traditionally
considered as undesirable products from protein production processes. However, being fully biocompatible, they have been recently
characterized as nanoparticulate inert materials useful as scaffolds for tissue engineering, with potentially wider applicability
in biomedicine and material sciences. Current protocols for inclusion body isolation from Escherichia coli usually offer between 95 to 99% of protein recovery, what in practical terms, might imply extensive bacterial cell contamination,
not compatible with the use of inclusion bodies in biological interfaces. |
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