| 多发性骨髓瘤与白细胞介素-6 |
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| 引用本文： | 王建军,洪丽萍,汤立军. 多发性骨髓瘤与白细胞介素-6[J]. 生命科学, 2010, 0(11): 1192-1195 |
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| 作者姓名： | 王建军 洪丽萍 汤立军 |
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| 作者单位： | 中南大学生物科学与技术学院分子生物学研究中心; |
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| 基金项目： | 国家自然科学基金项目(30400529); 湖南省杰出青年基金(04JJ1006); 中南大学米塔尔学生创新基金资助项目(08MX26) |
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| 摘 要： | 白细胞介素-6是多发性骨髓瘤(multiple myeloma,MM)瘤细胞生长和生存的关键因子,也是MM患者发病的主要因子。IL-6/IL-6R系统通过不同通路影响多发性骨髓瘤瘤细胞生长并导致患者骨损害、类风湿性关节炎等一系列并发症。针对IL-6/IL-6R系统的治疗方法将给MM的治疗带来重大的进展。
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| 关 键 词： | IL-6/IL-6R gp130 多发性骨髓瘤 |
Multiple myeloma and interleukin-6 |
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| WANG Jian-jun,HONG Li-ping,TANG Li-jun. Multiple myeloma and interleukin-6[J]. Chinese Bulletin of Life Sciences, 2010, 0(11): 1192-1195 |
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| Authors: | WANG Jian-jun HONG Li-ping TANG Li-jun |
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| Affiliation: | WANG Jian-jun,HONG Li-ping,TANG Li-jun (Molecular Biology Research Center,Institute of Life Science and Technology,Central South University,Changsha 410078,China) |
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| Abstract: | Interleukin-6 is a key growth and survival factor,which is involved in tumorigenesis of multiple myeloma.The proliferation of malignant cells in multiple myeloma are affected through different pathways of IL-6/IL-6R,which also could lead to bone damage,rheumatoid arthritis and some other complications in patients.Treatment of MM targeted IL-6/IL-6R system will provide a new therapeutic approach based on interruption of IL-6 mediated tumor cell growth in future. |
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| Keywords: | IL-6/IL-6R gp130 multiple myeloma |
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