| 细胞因子与酒精性肝病 |
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| 引用本文： | 刘丽琼,骆嘉,柯尊记. 细胞因子与酒精性肝病[J]. 生命科学, 2010, 0(12): 1241-1246 |
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| 作者姓名： | 刘丽琼 骆嘉 柯尊记 |
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| 作者单位： | 中国科学院上海生命科学研究院营养科学研究所营养与代谢重点实验室;上海中医药大学; |
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| 基金项目： | 国家自然科学基金项目(30870812); 国家重点基础研究发展计划(“973”项目)(2010CB912000;2007CB947100); 中国科学院上海生科院首席科学家计划(SIBS2008006) |
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| 摘 要： | 酒精性肝病(alcoholic liver disease,ALD)的发生发展过程与体内多种细胞因子有关,尤其是肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)和转化生长因子-β(transforming growth factor-β,TGF-β)在调节肝细胞的凋亡过程中具有重要作用。TNF-α可引起肝细胞凋亡与炎症反应等,抗TNF-α治疗能明显减轻酒精引起的肝损害;TGF-β具有增加细胞外基质的合成和抑制细胞外基质降解的作用,TGF-β1升高与肝纤维化密切相关。细胞因子可能是防治酒精性肝病的有效分子靶点。
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| 关 键 词： | 酒精性肝病 肿瘤坏死因子-α 转化生长因子 炎症反应 |
The role of cytokines in the progress of alcoholic liver disease |
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| LIU Li-qiong ,LUO Jia,KE Zun-Ji. The role of cytokines in the progress of alcoholic liver disease[J]. Chinese Bulletin of Life Sciences, 2010, 0(12): 1241-1246 |
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| Authors: | LIU Li-qiong LUO Jia KE Zun-Ji |
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| Affiliation: | LIU Li-qiong 1,2,LUO Jia1,KE Zun-Ji 1(1 Key Laboratory of Nutrition and Metabolism,Institute for Nutritional Sciences,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai 200031,China,2 Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China) |
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| Abstract: | Cytokines,especially tumor necrosis factor-a(TNF-a) and transforming growth factor-b(TGF-b),play an important role in the mechanisms in the pathogenesis of alcoholic liver disease(ALD),such as steatohepatitis,fibrosis,and cirrhosis.TNF-a and TGF-b are involved in the apoptotic liver cell death.TNF-a also takes part in the inflammation related to ALD.TNF-a antibody can distinctly alleviate alcohol-induced liver injury.TGF-b can increase extracellular matrix synthesis and inhibit its degradation;TGF-b1 is int... |
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| Keywords: | alcoholic liver disease tumor necrosis factor-a transforming growth factor inflammation |
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