| 昆虫蜕皮激素信号转导途径研究进展 |
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| 引用本文： | 赵小凡.昆虫蜕皮激素信号转导途径研究进展[J].生命科学,2010(12):1208-1214. |
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| 作者姓名： | 赵小凡 |
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| 作者单位： | 山东大学生命科学学院; |
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| 基金项目： | 国家自然科学基金项目(30710103901) |
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| 摘 要： | 蜕皮与变态是全变态昆虫典型的发育特征。调控昆虫蜕皮与变态的激素主要有蜕皮激素和保幼激素。目前已经阐明了蜕皮激素的核受体EcR及部分核信号转导途径,但蜕皮激素是否存在膜受体及膜信号转导途径研究很少。研究证明,蜕皮激素存在细胞质中的信号转导分子和途径,蜕皮激素通过NTF2和Ran调控EcR入核启动基因转录。蜕皮激素使细胞质中的热休克蛋白Hsc70部分入核与USP结合启动基因转录。蜕皮激素通过蛋白激酶PKC使伴侣蛋白calponin磷酸化,参与蜕皮激素信号途径的基因转录。这些研究结果说明蜕皮激素除了有核受体和核受体信号转导途径外,还存在细胞膜受体和细胞膜信号转导途径。
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| 关 键 词： | 蜕皮激素 信号转导途径 蜕皮 变态 组织重建 |
Progress in insect molting hormone signaling transduction pathways |
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| ZHAO Xiao-fan.Progress in insect molting hormone signaling transduction pathways[J].Chinese Bulletin of Life Sciences,2010(12):1208-1214. |
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| Authors: | ZHAO Xiao-fan |
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| Institution: | ZHAO Xiao-fan(School of Life Sciences,Shandong University,Jinan 250100,China) |
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| Abstract: | Molting and metamorphosis are the typical developmental characters in holometabolous insects.The processes are regulated by molting hormone(20E) and juvenile hormone(JH).The receptor of 20E known as EcR and the related nuclear transduction pathways are partially demonstrated.However,if there is membrane receptor and membrane transduction pathway are not known.Our studies in Helicoverpa armigera show that there are signaling transduction molecules and pathways for 20E in the cytoplasm.20E regulates EcR enter... |
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| Keywords: | molting hormone signaling transduction pathways molting metamorphosis tissue remodeling |
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