Species difference in the urinary excretion of isatinecic acid from the pyrrolizidine alkaloid retrorsine. |
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Authors: | P S Chu H J Segall |
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Affiliation: | Department of Veterinary Pharmacology and Toxicology, University of California, Davis 95616. |
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Abstract: | 1. The urinary excretion of the metabolites, isatinecic acid and pyrrolic metabolites from the pyrrolizidine alkaloid retrosine were lower in the resistant species, guinea-pigs, than the susceptible species, mice, hamsters and rats. 2. The urinary N-oxides levels, however, were higher in guinea-pigs relative to mice, hamsters and rats. 3. These results conform to the postulate that a common metabolic pathway exists between the formation of isatinecic acid and pyrrolic metabolites. 4. The resistance of guinea-pigs to PA poisoning is attributed to the high metabolism of PAs to N-oxides combined with a corresponding low conversion to pyrrolic metabolites. |
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