Evolutionary-biological peculiarities of transglutaminase. Structure,physiological functions,application |
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| Authors: | A. G. Shleikin N. P. Danilov |
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| Affiliation: | 1.St. Petersburg State University of Low-Temperature and Food Technologies,St. Petersburg,Russia |
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| Abstract: | Transglutaminase (TG; protein-glutamine γ-glutamyltransferase, EC 2.3.2.13) catalyzes the acyl transfer reactions that introduce the covalent ɛ-(γ-glutamyl)lysine bonds between proteins to form polymers of high mol. mass. Properties of the TG enzyme are described. Its structure is considered, there are described items of the TG life cycle and stability, its biological (physiological) role, and significance in pathology and medicine as well as obtaining the purified enzyme preparations and their use. TGs from different sources—of animal and microbial origin—are compared. Mechanism of catalysis of microbial TG is discussed. Characteristics of isoenzymes from different biological sources are presented. |
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