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Chromosome 4q;10q translocations; Comparison with different ethnic populations and FSHD patients

Authors:	Tsuyoshi?Matsumura Kanako?Goto Gaku?Yamanaka Je?Hyeon?Lee Cheng?Zhang Email author" target="_blank">Yukiko?K?Hayashi Email author Kiichi?Arahata

Institution:	(1) Department of Neuromuscular Research, National Institute of Neuroscience, NCNP, Tokyo, Japan;(2) Department of Neurology, Toneyama National Hospital, Osaka, Japan;(3) Department of Pediatrics, Tokyo Medical University, Tokyo, Japan;(4) Takara-Korea Biomedical Incorporation, Seoul, Korea;(5) Department of Neurology, First Affiliated Hospital, Sun Yan-sen University of Medical Science, Guangzhou, China

Abstract:	Background Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant disorder characterized by the weakness of facial, shoulder-girdle and upper arm muscles. Most patients with FSHD have fewer numbers of tandem repeated 3.3-kb KpnI units on chromosome 4q35. Chromosome 10q26 contains highly homologous KpnI repeats, and inter-chromosomal translocation has been reported.

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