Migration of Apicomplexa across biological barriers: the Toxoplasma and Plasmodium rides |
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Authors: | Tardieux Isabelle Ménard Robert |
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Affiliation: | Institut Cochin, UniversitéParis Descartes, Centre National de la Recherche Scientifique UMR 8104, 75014 Paris, France; Institut National de la Santéet de la Recherche Médicale U567, Paris, France; Unitéde Biologie et Génétique du Paludisme, Institut Pasteur, 28 Rue du Dr Roux, 75015 Paris, France |
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Abstract: | The invasive stages of Apicomplexa parasites, called zoites, have been largely studied in in vitro systems, with a special emphasis on their unique gliding and host cell invasive capacities. In contrast, the means by which these parasites reach their destination in their hosts are still poorly understood. We summarize here our current understanding of the cellular basis of in vivo parasitism by two well-studied Apicomplexa zoites, the Toxoplasma tachyzoite and the Plasmodium sporozoite. Despite being close relatives, these two zoites use different strategies to reach their goal and establish infection. |
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Keywords: | Apicomplexa zoites host cell invasion host cell traversal Plasmodium Toxoplasma |
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