Molecular cloning of MINK, a novel member of mammalian GCK family kinases, which is up-regulated during postnatal mouse cerebral development |
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| Authors: | Dan I Watanabe N M Kobayashi T Yamashita-Suzuki K Fukagaya Y Kajikawa E Kimura W K Nakashima T M Matsumoto K Ninomiya-Tsuji J Kusumi A |
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| Institution: | Kusumi Membrane Organizer Project, ERATO, JST, 5-11-33 Chiyoda, Nagoya, Japan. |
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| Abstract: | A new germinal center kinase (GCK) family kinase, Misshapen/NIKs-related kinase (MINK), has been cloned and its expression has been characterized in several tissues and various developmental stages of the mouse brain. MINK encodes a 1300 amino acid polypeptide, consisting of an N-terminal kinase domain, a proline-rich intermediate region, and a C-terminal GCK homology region. The expression of MINK is up-regulated during the postnatal development of the mouse brain. MINK activates the cJun N-terminal kinase and the p38 pathways. |
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