Changes occurring in the epithelium covering the bronchus-associated lymphoid tissue of rats after intratracheal challenge with horseradish peroxidase |
| |
Authors: | Gerda J van der Brugge-Gamelkoorn Marja van de Ende Taede Sminia |
| |
Institution: | (1) Department of Histology, Medical Faculty, Free University, Amsterdam, The Netherlands;(2) Department of Histology, Medical Faculty, Free University, P.O. Box 7161, NL-1007 MC Amsterdam, The Netherlands |
| |
Abstract: | Summary Changes occurring in the epithelium covering bronchus-associated lymphoid tissue (BALT) in the rat after several intratracheal administrations of horseradish peroxidase (HRP) were studied using morphological and ultrastructural methods. The epithelium is invaded by W3/ 25-positive (T-helper) lymphocytes, the BALT epithelial cells become Ia-positive and develop microvilli; there is an apparent loss of cilia. The number of non-ciliated cells in stimulated BALT increases. The non-ciliated cells can be subdivided into two cell types, one with electron-dense cytoplasm and cytoplasmic granules and the other without granules. The electron-density of the latter cell type is intermediate between that of the ciliated cells and that of the granulecontaining non-ciliated cells. The granule-containing cell types may be responsible for the uptake of antigens, while the other non-ciliated cell may be involved in the production of the secretory component and the passage of secretory IgA.Supported by a research grant from the Nederlands Astma Fonds |
| |
Keywords: | BALT Lymphoepithelium IgA response Ia-expression Rat |
本文献已被 SpringerLink 等数据库收录! |
|