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Toward novel HIV-1 integrase binding inhibitors: molecular modeling, synthesis, and biological studies |
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| Authors: | Mugnaini Claudia Rajamaki Suvi Tintori Cristina Corelli Federico Massa Silvio Witvrouw Myriam Debyser Zeger Veljkovic Veljko Botta Maurizio |
| Affiliation: | Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, Via A. De Gasperi 2, I-53100 Siena, Italy. |
| Abstract: | The identification of a novel hit compound as integrase binding inhibitor has been accomplished by means of virtual screening techniques. A small family of structurally related molecules has been synthesized and biologically evaluated with one of the compounds showing an IC(50)=12 microM. |
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