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Non-peptidic small molecule inhibitors of XIAP |
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| Authors: | Park Cheol-Min Sun Chaohong Olejniczak Edward T Wilson Alan E Meadows Robert P Betz Stephen F Elmore Steven W Fesik Stephen W |
| Institution: | Cancer Research, Global Pharmaceutical R and D, Abbott Laboratories, 100 Abbott Park Rd, Abbott Park, IL 60064-6010, USA. cheol-min.park@abbott.com |
| Abstract: | Non-peptidic small molecule SMAC mimetics were designed and synthesized that bind to the BIR3 domain of XIAP using structure-based design. Substituted five-membered heterocycles such as thiazoles and imidazoles were identified that serve as replacements for peptide fragments of the lead. |
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