Effects of the anesthetic agent propofol on neural populations |
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Authors: | Axel Hutt Andre Longtin |
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Institution: | (1) INRIA CR Nancy - Grand Est, CS20101, 54603 Villers-ls-Nancy Cedex, France;(2) Department of Physics, University of Ottawa, 150 Louis Pasteur, Ottawa, ON, K1N-6N5, Canada |
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Abstract: | The neuronal mechanisms of general anesthesia are still poorly understood. Besides several characteristic features of anesthesia
observed in experiments, a prominent effect is the bi-phasic change of power in the observed electroencephalogram (EEG), i.e.
the initial increase and subsequent decrease of the EEG-power in several frequency bands while increasing the concentration
of the anaesthetic agent. The present work aims to derive analytical conditions for this bi-phasic spectral behavior by the
study of a neural population model. This model describes mathematically the effective membrane potential and involves excitatory
and inhibitory synapses, excitatory and inhibitory cells, nonlocal spatial interactions and a finite axonal conduction speed.
The work derives conditions for synaptic time constants based on experimental results and gives conditions on the resting
state stability. Further the power spectrum of Local Field Potentials and EEG generated by the neural activity is derived
analytically and allow for the detailed study of bi-spectral power changes. We find bi-phasic power changes both in monostable
and bistable system regime, affirming the omnipresence of bi-spectral power changes in anesthesia. Further the work gives
conditions for the strong increase of power in the δ-frequency band for large propofol concentrations as observed in experiments. |
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Keywords: | General anesthesia Neural fields EEG Power spectrum |
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