Differential activity of innate defense antimicrobial peptides against <Emphasis Type="Italic">Nocardia</Emphasis> species |
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| Authors: | Siegbert Rieg Benjamin Meier Eva Fähnrich Anja Huth Dirk Wagner Winfried V Kern Hubert Kalbacher |
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| Institution: | 1.Center for Infectious Diseases & Travel Medicine,University Medical Center,Freiburg,Germany;2.Medical and Natural Sciences Research Center,University of Tübingen,Tübingen,Germany |
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| Abstract: | Background Members of the genus Nocardia are ubiquitous environmental saprophytes capable to cause human pulmonary, disseminated and cutaneous nocardiosis or bovine
mastitis. Innate immunity appears to play an important role in early defense against Nocardia species. To elucidate the contribution of antimicrobial peptides (AMPs) in innate defense against Nocardia, the activity of human α-defensins human neutrophil peptides (HNPs) 1-3, human β-defensin (hBD)-3 and cathelicidin LL-37
as well as bovine β-defensins lingual and tracheal antimicrobial peptides (LAP, TAP) and bovine neutrophil-derived indolicidin
against four important Nocardia species was investigated. |
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