Chemical modulators of the innate immune response alter gypsy moth larval susceptibility to <Emphasis Type=Italic>Bacillus thuringiensis</Emphasis>期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Chemical modulators of the innate immune response alter gypsy moth larval susceptibility to Bacillus thuringiensis

Authors:	Nichole A Broderick Jo Handelsman

Affiliation:	(1) Department of Entomology, University of Wisconsin, 53706 Madison, WI, USA;(2) Department of Bacteriology, University of Wisconsin, 53706 Madison, WI, USA;(3) Department of Plant Pathology, University of Wisconsin, 53706 Madison, WI, USA;(4) Global Health Institute, EPFL, Lausanne, 1004, Switzerland;(5) Department of Molecular, Cellular and Developmental Biology, Yale University, 06520 New Haven, CT, USA

Abstract:	Background The gut comprises an essential barrier that protects both invertebrate and vertebrate animals from invasion by microorganisms. Disruption of the balanced relationship between indigenous gut microbiota and their host can result in gut bacteria eliciting host responses similar to those caused by invasive pathogens. For example, ingestion of Bacillus thuringiensis by larvae of some species of susceptible Lepidoptera can result in normally benign enteric bacteria exerting pathogenic effects.

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