Angiotensin II and angiotensin-(1-7) decrease sFlt1 release in normal but not preeclamptic chorionic villi: an <Emphasis Type="Italic">in vitro</Emphasis> study期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Angiotensin II and angiotensin-(1-7) decrease sFlt1 release in normal but not preeclamptic chorionic villi: an in vitro study

Authors:	Lauren Anton David C Merrill Liomar AA Neves Courtney Gruver Cheryl Moorefield K Bridget Brosnihan

Affiliation:	1.Hypertension and Vascular Research Center,Wake Forest University School of Medicine,Winston-Salem,USA;2.Department of Obstetrics and Gynecology,Wake Forest University School of Medicine,Winston-Salem,USA

Abstract:	Background During preeclampsia, placental angiogenesis is impaired. Factors released from the placenta including vascular endothelial growth factor (VEGF), placental growth factor (PLGF), soluble VEGF receptor 1 (sFlt1), and soluble endoglin (sEng) are regulatory molecules of placental development and function. While the renin angiotensin system has been shown to regulate angiogenic factors in other research fields, these mechanisms have not been extensively studied during pregnancy.

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