<Emphasis Type="Italic">Candida dubliniensis</Emphasis>: Epidemiology and Phenotypic Methods for Identification |
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Authors: | Érico Silva Loreto Liliane A Scheid Cristina W Nogueira Gilson Zeni Janio M Santurio Sydney H Alves |
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Institution: | 1.Departamento de Química, Centro de Ciências Naturais e Exatas,Universidade Federal de Santa Maria,Santa Maria,Brazil;2.Curso de Pós gradua??o em Ciências Farmacêuticas,Universidade Federal de Santa Maria,Santa Maria,Brazil;3.Departamento de Microbiologia e Parasitologia,Universidade Federal de Santa Maria,Santa Maria,Brazil |
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Abstract: | Candida dubliniensis is an emerging pathogen first described in 1995, which shares many phenotypic features with Candida albicans and therefore may be misidentified in microbial laboratories. Despite various phenotypic techniques described in the literature
to differentiate the two species, the correct identification of C. dubliniensis remains problematic due to phenotypic similarities between these species. Thus, as the differences between both are best
characterized at genetic levels, several molecular methods have been proposed to provide a specific and rapid identification
of this species. Epidemiological studies have shown that C. dubliniensis is prevalent throughout the world and it is primarily associated with oral carriage and oropharyngeal infections in patients
infected with human immunodeficiency virus (HIV). However, data acquired from its isolation from other healthy and immunocompromised
patients are variable, and there is still no real consensus on the epidemiological relevance of this species. In this article,
we review the various phenotypic methods used in the identification of C. dubliniensis and the epidemiological impact of this new species. |
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