Human TGFalpha-derived peptide TGFalphaL3 fused with superantigen for immunotherapy of EGFR-expressing tumours |
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| Authors: | Quanbin Xu Xiaojuan Zhang Junjie Yue Chuanxuan Liu Cheng Cao Hui Zhong Qingjun Ma |
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| Institution: | (1) Beijing Institute of Biotechnology, Taiping Road 27, Beijing, PR China;(2) Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, No.1 West Beichen Road, Beijing, PR China |
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| Abstract: | Background Monoclonal antibodies have been employed as targeting molecules of superantigen for the preclinical treatment of a variety
of tumours. However, other targeting molecules, such as tumour-related ligands or peptides, are less exploited. Here, we tested
other targeting molecules by genetically fusing the third loop of transforming growth factor alpha (TGFalphaL3) to mutant
staphylococcal enterotoxin A (SEAD227A). |
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