VEGF and bFGF mRNA Are Expressed in Ethylnitrosourea-Induced Experimental Rat Gliomas |
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Authors: | Tomoaki Okimoto Isao Shimokawa Yoshikazu Higami Takayoshi Ikeda |
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Institution: | (1) Department of Pathology, Nagasaki University School of Medicine, 1-12-4 Sakamoto, Nagasaki, 852, Japan |
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Abstract: | 1. Which angiogenic growth factors actually mediate tumor growth in ethylnitrosourea (ENU)-induced gliomas in rats was examined.2. In situ hybridization histochemistry with digoxigenin-labeled oligonucleotide probes was used to investigate the cellular expression and distribution of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) mRNAs in ENU-induced gliomas.3. Both VEGF and bFGF mRNAs were not detected in normal gial cells but in ENU-induced glioma cells.4. Our results suggest that the growth of ENU-induced glioma may be regulated by multiple angiogenic growth factors and that these gliomas may proliferate by synthesizing such growth factors. |
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Keywords: | vascular endothelial growth factor basic fibroblast growth factor ethylnitrosourea-induced rat glioma digoxigenin in situ hybridization |
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