Picornavirus RNA translation: roles for cellular proteins |
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| Authors: | Belsham G J Sonenberg N |
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| Affiliation: | BBSRC Institute for Animal Health, Pirbright, Woking, Surrey, UK GU24 0NF. graham.belsham@bbsrc.ac.uk |
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| Abstract: | Picornavirus RNA is translated within cells even when cellular cap-dependent protein synthesis is blocked. The efficiency of recognition of the viral RNA by the translational apparatus can determine viral tropism. The roles of cellular translation-initiation factors and other RNA-binding proteins in viral RNA-mediated protein synthesis are discussed. |
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