| 谷氨酸致痫大鼠海马内spinophilin免疫反应的变化 |
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| 引用本文： | 王争艳,周厚纶,刘庆莹,魏瑛,童逸龄,朱长庚. 谷氨酸致痫大鼠海马内spinophilin免疫反应的变化[J]. 中国组织化学与细胞化学杂志, 2002, 11(3): 244-247 |
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| 作者姓名： | 王争艳 周厚纶 刘庆莹 魏瑛 童逸龄 朱长庚 |
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| 作者单位： | 华中科技大学同济医学院人体解剖学教研室,武汉,430030 |
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| 基金项目： | 国家自然科学基金资助 (No 30 170 4 84 ) |
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| 摘 要： | 目的 研究spinophilin与癫痫发病的关系。方法 采用侧脑室注射L-谷氨酸钠6μl（50mg/ml)制作大鼠癫痫模型。动物存活2小时，然后用免疫组织化学方法观察大鼠海巴内spinophilin表达的变化。结果 实验组大鼠海马CAI及CA3区阳性反应产物较对照组明显增多。结论 提示spinophilin可能参与了癫痫的发生。但是其机理尚需要进一步探索。
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| 关 键 词： | 免疫组织化学 癫痫 谷氨酸 致痫大鼠 海马 spinophilin 免疫反应 |
| 修稿时间： | 2002-03-01 |
CHANGES OF SPINOPHILIN IMMUNOREACTION IN THE HIPPOCAMPUS OF RATS WITH EPILEPSY INDUCED BY GLUTAMATE |
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| Wang Zhengyan,Zhou Houlun,Liu Qingying,Wei Ying,Tong Yiling,Zhu Changgeng. CHANGES OF SPINOPHILIN IMMUNOREACTION IN THE HIPPOCAMPUS OF RATS WITH EPILEPSY INDUCED BY GLUTAMATE[J]. Chinese Journal of Histochemistry and Cytochemistry, 2002, 11(3): 244-247 |
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| Authors: | Wang Zhengyan Zhou Houlun Liu Qingying Wei Ying Tong Yiling Zhu Changgeng |
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| Abstract: | Objective To explore the relationship between spinophilin and epilepsy Method The epilepsy was induced by injecting L glutamate sodium into the lateral ventricle,and the ratswere sacrificed 2 hours after the onset of epileptic activity The changes in spinophilin expression were examined by means of immunohistochemistry Result Immunoreactionof spinophilin increased in hippocampal CA1 and CA3 areas of the experimental group Conclusion The results indicate that spinophilin may play a role in the epileptic susceptibility |
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| Keywords: | Epilepsy Hippocampus Spinophilin Immunohistochemistry Rat |
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