Lack of global meiotic sex chromosome inactivation,and paucity of tissue-specific gene expression on the <Emphasis Type="Italic">Drosophila X</Emphasis> chromosome |
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| Authors: | Lyudmila M Mikhaylova Dmitry I Nurminsky |
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| Institution: | (1) Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, USA;(2) Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, USA |
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| Abstract: | Background Paucity of male-biased genes on the Drosophila X chromosome is a well-established phenomenon, thought to be specifically linked to the role of these genes in reproduction
and/or their expression in the meiotic male germline. In particular, meiotic sex chromosome inactivation (MSCI) has been widely
considered a driving force behind depletion of spermatocyte-biased X-linked genes in Drosophila by analogy with mammals, even though the existence of global MCSI in Drosophila has not been proven. |
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