Nanoscaled carborane ruthenium(II)-arene complex inducing lung cancer cells apoptosis |
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| Authors: | Gen Zhang Chunhui Wu Hongde Ye Hong Yan Xuemei Wang |
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| Institution: | (1) State Key Lab of Bioelectronics (Chien-Shiung Wu Lab), Department of Biological Science, Medical Engineering Southeast University, Nanjing, 210096, PR China;(2) State Key Lab of Coordination Chemistry, School of Chemistry and Chemical Engineering, The Joint Laboratory of Metal Chemistry, Nanjing University, Nanjing, Jiangsu, 210093, PR China |
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| Abstract: | Background The new ruthenium(II)-arene complex, which bearing a carborane unit, ruthenium and ferrocenyl functional groups, has a novel
versatile synthetic chemistry and unique properties of the respective material at the nanoscale level. The ruthenium(II)-arene
complex shows significant cytotoxicity to cancer cells and tumor-inhibiting properties. However, ruthenium(II)-arene complex
of mechanism of anticancer activity are scarcely explored. Therefore, it is necessary to explore ruthenium(II)-arene complex
mechanism of anticancer activity for application in this area. |
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