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An unexpectedly high degree of specialization and a widespread involvement in sterol metabolism among the |
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| Authors: | Nicholas N Lyssenko Yana Miteva Simon Gilroy Wendy Hanna-Rose Robert A Schlegel |
| Affiliation: | (1) Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, 16802, USA;(2) Department of Biology, The Pennsylvania State University, University Park, Pennsylvania, 16802, USA;(3) The Huck Institutes of the Life Sciences at the Pennsylvania State University, University Park, Pennsylvania, 16802, USA;(4) Department of Cell Biology, NC10, Lerner Research Institute, 9500 Euclid Avenue, Cleveland Clinic Foundation, Cleveland, Ohio, 44195, USA;(5) Department of Physiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA;(6) Department of Botany, University of Wisconsin, B117 Birge Hall, 53706 Madison, Wisconsin, USA |
| Abstract: | BackgroundP-type ATPases in subfamily IV are exclusively eukaryotic transmembrane proteins that have been proposed to directly translocate the aminophospholipids phosphatidylserine and phosphatidylethanolamine from the exofacial to the cytofacial monolayer of the plasma membrane. Eukaryotic genomes contain many genes encoding members of this subfamily. At present it is unclear why there are so many genes of this kind per organism or what individual roles these genes perform in organism development. |
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