Influence of decreased intracellular glutathione level on the mutagenicity of patulin in cultured mouse lymphoma cells

The mutagenicity of the mycotoxin patulin was assessed by the thymidine kinase mutation assay, which is based on point mutations and deletions. Patulin was mutagenic in cultured mouse lymphoma cells and the mutagenicity was significantly increased in cells pretreated with buthionine sulfoximine, which reduces intracellular glutathione levels. Presented at the 26^th Mykotoxin-Workshop in Herrsching, Germany, May 17–19, 2004 Financial support Deutsche Forschungsgemeinschaft (Grant Me 574/14-2)