Specific, reversible inactivation of yeast beta-hydroxy-beta-methylglutraryl-CoA reductase by CoA.

A non-stoichiometric material [Na₄(5′-IMP)₂·15H₂O]_0.2[Na₂(Pt(5′-IMP)₂ (trimethylenediamine))·13.5H₂O]_0.8 has been prepared and investigated by single-crystal X-ray methods and ¹H and ¹³C nmr spectroscopy. The compound is isomorphous with the monosodium and disodium salts of 5′-IMP and two Pt(II)-5′-IMP compounds previously reported to be non-stoichiometric. However, the structural changes in the packing motif of the 5′-IMP molecules induced on Pt(II) coordination are uniform only if the 5′-IMP complex containing (NH₃)₂Pt(II) is stoichiometric. Preliminary studies on the latter complex, synthesized in our laboratories, demonstrate that the complex is indeed stoichiometric.