Comparison between excessive grooming induced by bombesin or by ACTH: the differential elements of grooming and development of tolerance |
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Authors: | T B Van Wimersma Greidanus D K Donker F F Van Zinnicq Bergmann R Bekenkamp C Maigret B Spruijt |
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Affiliation: | Rudolf Magnus Institute for Pharmacology, University of Utrecht, Medical Faculty, Vondellaan 6 3521 GD Utrecht, The Netherlands |
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Abstract: | Bombesin and ACTH-(1-24) induce a dose dependent increase in grooming behavior. Lower doses of bombesin induce a more general type of compulsive grooming in which most elements are involved, whereas higher amounts of bombesin induce a shift towards the element scratching at the cost of bodily grooming and sexual grooming. In contrast ACTH-(1-24) induces a dose dependent increase of all elements of grooming. It is concluded that the grooming displayed by animals treated with ACTH-(1-24) or with bombesin is of a completely different nature. In addition it is observed that under the conditions used tolerance occurs for the grooming inducing effect of ACTH-(1-24), but not for that of bombesin. Moreover, it appears that no cross tolerance exists between bombesin and ACTH-(1-24). |
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Keywords: | Bombesin ACTH-(1–24) Grooming behavior Tolerance |
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