Formation of multinucleated giant cells from circulating blood cells cultivated in diffusion chambers.

Autologous circulating rabbit blood cells have been cultivated in Millipore diffusion chambers implanted intraperitoneally for 13 days. During this period multinucleated giant cells were formed within the diffusion chambers, confirming a hematogenous origin of these cells. The diffusion chamber technique might be helpful for the investigations of factors initiating the formation of multinucleated giant cells.