Peptide Design Principles for Antimicrobial Applications |
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| Institution: | 1. Synthetic Biology Group, MIT Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA;2. Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA;3. Department of Biological Engineering, and Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA;4. Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA;5. The Center for Microbiome Informatics and Therapeutics, Cambridge, MA 02139, USA;6. Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Santo André, São Paulo 09210580, Brazil;1. Department of Respiratory Medicine, Beijing Hospital, Beijing 100730, China;2. School of Life Science, Liaoning Normal University, Dalian 116081, China;3. Ling-Nan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, China;4. Liaoning Provincial Key Laboratory of Biotechnology and Drug Discovery, Liaoning Normal University, Dalian 116081, China;1. Centro de Análises Proteômicas e Bioquímicas, Pós-Graduação em Ciências Genômicas e Biotecnologia Universidade Católica de Brasília, Brasília, DF, Brazil;2. S-Inova Biotech, Pós-graduação em Biotecnologia, Universidade Católica Dom Bosco, Campo Grande, MS, Brazil;3. Porto Reports, Brasília, DF, Brazil;1. Institute for Molecular Bioscience, The University of Queensland, 4072 Brisbane, QLD, Australia |
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| Abstract: | The increased incidence of bacterial resistance to available antibiotics represents a major global health problem and highlights the need for novel anti-infective therapies. Antimicrobial peptides (AMPs) represent promising alternatives to conventional antibiotics. AMPs are versatile, have almost unlimited sequence space, and can be tuned for broad-spectrum or specific activity against microorganisms. However, several obstacles remain to be overcome in order to develop AMPs for medical use, such as toxicity, stability, and bacterial resistance. We lack standard experimental procedures for quantifying AMP activity and do not yet have a clear picture of the mechanisms of action of AMPs. The rational design of AMPs can help solve these issues and enable their use as new antimicrobials. Here we provide an overview of the main physicochemical features that can be engineered to achieve enhanced bioactivity and describe current strategies being used to design AMPs. |
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