Heterogeneity in Bacterial Specialized Metabolism |
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| Institution: | 1. Fachbereich Biowissenschaften, Goethe Universität Frankfurt, Frankfurt am Main, Germany;2. Buchmann Institute for Molecular Life Sciences (BMLS), Goethe Universität Frankfurt, 60438 Frankfurt am Main, Germany;1. LOEWE Center for Synthetic Microbiology & Department of Physics, Marburg, Germany;2. Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany;3. Physik Department, Technische Universität München, Garching, Germany;1. Research Center for Infectious Diseases ZINF, University of Würzburg, 97080 Würzburg, Germany;2. Institute for Molecular Infection Biology IMIB, University of Würzburg, 97080 Würzburg, Germany;3. National Centre for Biotechnology (CNB-CSIC), 28050 Madrid, Spain |
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| Abstract: | Specialized metabolites (SMs) like typical antibiotics, signaling molecules or other bioactive compounds of bacterial origin (sometimes also used in human therapy) are often complex natural products that are costly for the cell to make. Several bacterial taxa are known to produce multiple SM classes in parallel and therefore a division of labor within a clonal population of bacteria might be beneficial. In this review, examples of SM of gram-negative and gram-positive bacterial taxa that are produced by different cell types are presented, and the possibility that such a heterogeneity is more widespread in SM biosynthesis is discussed. In addition, tools to study SM production at the single cell level are presented. |
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