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Endogenous sterol intermediates of the mevalonate pathway regulate HMGCR degradation and SREBP-2 processing |
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| Affiliation: | 2. State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China |
| Abstract: | |
| Keywords: | mevalonate lanosterol sterol intermediates 3-hydroxy-3-methylglutaryl-coenzyme A reductase degradation sterol regulatory element-binding protein-2 cleavage clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR associated protein 9 (Cas9) sterol regulatory element-binding protein-2 |
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