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Comparative quantitative systems pharmacology modeling of anti-PCSK9 therapeutic modalities in hypercholesterolemia
Affiliation:2. Clinical Pharmacology & Safety Sciences R&D BioPharmaceuticals, AstraZeneca, Boston, MA;4. Clinical Pharmacology & Safety SciencesCardiovascular, R&D BioPharmaceuticals, AstraZeneca, Gothenburg, Sweden;8. Renal and Metabolism R&D BioPharmaceuticals, AstraZeneca, Gothenburg, Sweden;11. I. M. Sechenov First Moscow State Medical University of the Russian Ministry of Health Moscow, Russia
Abstract:
Keywords:atherosclerosis  lipoproteins  cholesterol metabolism  plasma proprotein convertase subtilisin/kexin type 9  quantitative modeling  translational pharmacology
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