MAPK8IP1/JIP1 regulates the trafficking of autophagosomes in neurons |
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| Authors: | Meng-meng Fu Erika L F Holzbaur |
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| Institution: | 01.Department of Physiology; University of Pennsylvania Perelman School of Medicine; Philadelphia, PA USA;†Current affiliation: Department of Neurobiology; Stanford University School of Medicine; Stanford, CA USA |
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| Abstract: | Autophagy is a spatially regulated process in axons; autophagosomes form preferentially in the distal axon tip then move actively and processively toward the cell body. Despite the primarily unidirectional transport observed in live-cell imaging experiments, both anterograde-directed KIF5/kinesin-1 motors and retrograde-directed dynein motors are tightly associated with axonal autophagosomes. Here, we discuss our recent work identifying the scaffolding protein MAPK8IP1/JIP1 (mitogen-activated protein kinase 8 interacting protein 1) as a key regulator of autophagosome transport in neurons. MAPK8IP1 tightly coordinates motor activity to ensure the fidelity of retrograde autophagosome transport in the axon. |
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| Keywords: | autophagosomes axonal transport dynactin dynein JIP1 kinesin LC3 LIR MKP1 motor regulation |
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