Design, synthesis and structure-activity relationships of 5-alkylaminolquinolines as a novel series of CRF1 receptor antagonists |
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| Authors: | Takeda Kunitoshi Terauchi Taro Shin Kogyoku Ino Mitsuhiro Shibata Hisashi Yonaga Masahiro |
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| Institution: | Medicinal Chemistry, Tsukuba Research Laboratories, Eisai Co., Ltd, 5-1-3 Tokodai, Tsukuba-shi, Ibaraki 300-2635, Japan. k5-takeda@hhc.eisai.co.jp |
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| Abstract: | A series of 5-alkylaminolquinolines was designed and synthesized as potential novel CRF(1) receptor antagonists. The structure-activity relationships (SARs) of the substituents on each position (R(2), R(3), R(5) and R(5')) were investigated. |
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