| 哺乳动物核质重组胚后成性重序的机制 |
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| 引用本文： | 徐世晶,徐银学,刘红林.哺乳动物核质重组胚后成性重序的机制[J].遗传,2005,27(3):473-480. |
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| 作者姓名： | 徐世晶 徐银学 刘红林 |
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| 作者单位： | 南京农业大学动物科技学院，南京 210095 |
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| 基金项目： | 国家自然科学基金“组蛋白去乙酰化对小鼠核移植胚基因组重序的调控”主题项目资助(编号:30371034)~~ |
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| 摘 要： | 研究表明，供体核不完全或者不正确的后成性重序可能是核移植失败的主要原因。本篇文章综述了哺乳动物核质重组胚中存在的几种不同的后成性重序机制，包括DNA甲基化、染色质重构、基因组印记与X染色体失活、端粒维持以及其他后成性遗传机制。理解重组胚后成性重序的机制将有助于我们解决核移植技术中存在的问题，进而促进它的应用。
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| 关 键 词： | 后成性重序 重组胚 核移植 |
| 文章编号： | 0253-9772(2005)03-0473-08 |
| 收稿时间： | 2004-03-05 |
| 修稿时间： | 2004年3月5日 |
Mechanisms of Epigenetic Reprogramming in Mammalian Reconstructed Embryos Produced by Nuclear Transfer |
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| XU Shi-Jing,XU Yin-Xue,LIU Hong-Lin.Mechanisms of Epigenetic Reprogramming in Mammalian Reconstructed Embryos Produced by Nuclear Transfer[J].Hereditas,2005,27(3):473-480. |
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| Authors: | XU Shi-Jing XU Yin-Xue LIU Hong-Lin |
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| Institution: | College of Animal Science , Nanjing Agricultural University , Nanjing 210095,China |
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| Abstract: | Circumstantial studies indicated that incomplete or inappropriate epigenetic reprogramming of donor nuclei was likely to be the primary reason for failures in nuclear transfer. In this view, we discussed the roles of several epigenetic mechanisms, including DNA methylation, chromatin remodeling, imprinting and X chromosome inactivation, (telomere) maintenance, and epigenetic inheritance in the observed abnormalities in clones from different species. Understanding the mechanisms underlying epigenetic reprogramming control will help us resolve the inherent problems in (nuclear) transfer technology and make its applications promising. |
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| Keywords: | nuclear transfer reconstructed embryos epigenetic reprogramming |
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