Genetic mapping of the whirler mutation |
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Authors: | Michael JC Rogers Jane Fleming Brent W Kiernan Philomena Mburu Anabel Varela Steve DM Brown Karen P Steel |
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Institution: | (1) MRC Institute of Hearing Research, University Park, Nottingham NG7 2RD, UK, GB;(2) MRC Mammalian Genetics Unit and UK Mouse Genome Centre, Harwell, Didcot, Oxfordshire OX11 ORD, UK, GB |
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Abstract: | The whirler (wi) mutation on mouse Chromosome (Chr) 4 results in an autosomal recessive neuroepithelial deafness and vestibular dysfunction
exhibited as a characteristic shaker-waltzer behavior (deafness, circling, and head-bobbing). We have constructed a genetic
linkage map across the wi region in both an interspecific (wi/wi× CAST/Ei)F1×wi/wi] backcross (n = 817) and an intraspecific (wi/wi× CBA/Ca)F1×wi/wi)] backcross (n = 335). In the interspecific backcross, wi was found to be non-recombinant with Orm1, 0.12 cM distal of D4Mit87 and Ambp, and 0.12 cM proximal of CD301. In the intraspecific backcross, wi was found to be non-recombinant with Orm1 and D4Mit244, 0.3 cM distal of Mup1, and 0.6 cM proximal of Tnc. We also report a family from the interspecific backcross that shows evidence of multiple recombinations across the region
of mouse Chr 4 around the wi locus. These rearrangements appear specific to both the region and the family.
Received: 10 July 1998 / Accepted: 19 January 1999 |
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