BMP signaling in the epiblast is required for proper recruitment of the prospective paraxial mesoderm and development of the somites |
| |
Authors: | Miura Shigeto Davis Shannon Klingensmith John Mishina Yuji |
| |
Affiliation: | Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, MD C4-10, C458, Research Triangle Park, NC 27709, USA. |
| |
Abstract: | Bmpr1a encodes the BMP type IA receptor for bone morphogenetic proteins (BMPs), including 2 and 4. Here, we use mosaic inactivation of Bmpr1a in the epiblast of the mouse embryo (Bmpr-MORE embryos) to assess functions of this gene in mesoderm development. Unlike Bmpr1a-null embryos, which fail to gastrulate, Bmpr-MORE embryos initiate gastrulation, but the recruitment of prospective paraxial mesoderm cells to the primitive streak is delayed. This delay causes a more proximal distribution of cells with paraxial mesoderm character within the primitive streak, resulting in a lateral expansion of somitic mesoderm to form multiple columns. Inhibition of FGF signaling restores the normal timing of recruitment of prospective paraxial mesoderm and partially rescues the development of somites. This suggests that BMP and FGF signaling function antagonistically during paraxial mesoderm development. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|