Phospholipase D in endocytosis and endosomal recycling pathways |
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| Authors: | Julie G. Donaldson |
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| Affiliation: | Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 50, Room 2503, Bethesda, MD 20892, USA |
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| Abstract: | The discovery that Arf GTPases, mediators of membrane traffic, activate phospholipase D (PLD) raised the possibility that Arfs could facilitate membrane traffic by altering membrane lipid composition. PLD hydrolyzes phosphatidylcholine to generate phosphatidic acid (PA), a lipid that favors membranes with negative curvature and thus can facilitate both membrane fission and fusion. This review examines studies that have reported a role for PLD in endocytosis and membrane recycling from endocytic pathways. |
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| Keywords: | Arf6 Endocytosis Recycling Membrane traffic Phospholipase D |
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