In vitro prominent bone regeneration by release zinc ion from Zn-modified implant |
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| Authors: | Yusa Kazuyuki Yamamoto Osamu Fukuda Masayuki Koyota Souichi Koizumi Yukio Sugiyama Toshihiro |
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| Institution: | aDepartment of Biochemistry, Akita University Graduate School of Medicine, Akita, Japan;bDepartment of Bio-System Engineering, Graduate School of Science and Engineering, Yamagata University, Yonezawa, Japan;cDivision of Dentistry and Oral Surgery, Akita University Hospital, Akita, Japan |
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| Abstract: | Zinc is one of the trace elements which induce the proliferation and the differentiation of the osteoblast. In the previous study, we found that zinc ions (Zn2+ ion)-releasing titanium implants had excellent bone fixation using a rabbit femurs model. In this study, we isolated the Zn2+ ions (eluted Zn2+ ion; EZ) released from the implant surface, and evaluated the effect of EZ on the osteogenesis of human bone marrow-derived mesenchymal cells (hBMCs). In the result, it was found that the EZ stimulated cell viability, osteoblast marker gene (type I collagen, osteocalcin (OC), alkaline phosphatase (ALP) and bone sialoprotein (BSP)) expressions and calcium deposition in hBMCs. |
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| Keywords: | Biological response Bone regeneration Zinc ion hBMCs |
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