|
|||||
|
|
HMG-CoA reductase inhibitor augments the serum total cholesterol-lowering effect of human adipose tissue-derived multilineage progenitor cells in hyperlipidemic homozygous Watanabe rabbits |
|
| Authors: | Saga Ayami Okura Hanayuki Soeda Mayumi Tani Junko Fumimoto Yuichi Komoda Hiroshi Moriyama Mariko Moriyama Hiroyuki Yamashita Shizuya Ichinose Akihiro Daimon Takashi Hayakawa Takao Matsuyama Akifumi |
| Affiliation: | aDepartment of Somatic Stem Cell Therapy and Health Policy, Foundation for Biomedical Research and Innovation, TRI305, 1-5-4 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan;bPharmaceutical Research and Technology Institute, Kinki University, 3-4-1 Kowakae, Higashi-Osaka, Osaka 577-8502, Japan;cDivision of Cardiology, Department of Internal Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan;dDepartment of Plastic Surgery, Kobe University Hospital, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo 660-0017, Japan;eDivision of Biostatistics, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan |
| Abstract: | Familial hypercholesterolemia (FH) is an autosomal codominant disease characterized by high concentrations of proatherogenic lipoproteins secondary to deficiency in low-density lipoprotein (LDL) receptor. We reported recently the use of in situ stem cell therapy of human adipose tissue-derived multilineage progenitor cells (hADMPCs) in lowering serum total cholesterol in the homozygous Watanabe heritable hyperlipidemic (WHHL) rabbits, an animal model of homozygous FH. Here we demonstrate that pravastatin, an HMG-CoA reductase inhibitor, augmented the cholesterol-lowering effect of transplanted hADMPCs and enhanced LDL clearance in homozygous WHHL rabbit. The results suggest the potential beneficial effects of in situ stem cell therapy in concert with appropriately selected pharmaceutical agents, in regenerative medicine. |
| Keywords: | ADMPC WHHL HMG-CoA reductase inhibitor Pravastatin Cholesterol Cell therapy |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |