Role of JAK/STAT signaling in neuroepithelial stem cell maintenance and proliferation in the Drosophila optic lobe |
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| Authors: | Wang Wei Li Yonggang Zhou Liya Yue Haitao Luo Hong |
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| Institution: | aDepartment of Chemical and Material Engineering, National Yulin University of Science and Technology, Taiwan;bDepartment of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, Taiwan;cDepartment of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Taiwan;dDepartment of Fiber and Composite Materials, Feng Chia University, Taiwan;eDepartment of Urology, St. Joseph Hospital, Taiwan;fDepartment of Nephrology, Chi-Mei Medical Center, Taiwan;gDepartment of Family Medicine, Chi-Mei Medical Center, Taiwan;hNational Sun Yat-Sen University-Kaohsiung Medical University Joint Research Center, Taiwan;iCenter for Research Resources and Development, Kaohsiung Medical University, Taiwan;jCenter of Excellence for Environmental Medicine, Kaohsiung Medical University, Taiwan |
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| Abstract: | Human urine contains a large number of proteins and peptides (the urinary proteome). Global analysis of the human urinary proteome is important for understanding urinary tract diseases. Bladder cancer is the most common urological cancer with higher incidence rates in endemic areas of Blackfoot disease (BFD) in southern Taiwan. The aim of this study was to use the proteomic approach to establish urinary protein biomarkers of bladder cancer. ADAM28, identified by proteomic approaches and confirmed by Western blotting, showed significant differences compared with normal individuals, so it may be a biomarker of bladder cancer. |
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| Keywords: | Proteomics Bladder cancer Urinary protein Protein identification Biomarker |
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