Three new compounds from the plant Lippia alva as inhibitors of chemokine receptor 5 (CCR5) |
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| Authors: | Hegde Vinod R Pu Haiyan Patel Mahesh Das Pradip R Strizki Julie Gullo Vincent P Chou Chuan-Chu Buevich Alexei V Chan Tze-Ming |
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| Institution: | Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. vinod.hegde@spcorp.com |
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| Abstract: | The 70% aqueous methanol extract of the Peruvian plant Lippia alva (Verbenaceae) was found to contain three novel compounds, 1, 2, and 3, which were identified as inhibitors of the chemokine receptor CCR5. The structures of 1-3 were established based on extensive NMR studies. Compounds 1-3 inhibited CCR5 receptor signaling as measured by a calcium mobilization assay with IC(50) values of 5.5, 6.0, and 7.2 microg/mL, respectively. |
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