Enumeration and structural assessment of peritoneal macrophages during progressive protein deficiency in rats |
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Authors: | U R Iyengar U K Vakil |
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Institution: | (1) Biochemistry and Food Technology Division, Bhabha Atomic Research Centre, 400 085 Trombay, Bombay, India |
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Abstract: | The effects of protein malnutrition on responsiveness of macrophages to proteosepeptone stimulation and on their chemical
composition were investigated. Relative number of resident macrophages in rat peritoneal cavity was reduced by about 50 %
during 4 weeks on 3 % protein diet. Similarly, decreased migration capacity of the circulating macrophages to the peritoneal
exudate in response to the stimulant, was observed in protein-fasted rat compared to that in the 20 % protein-fed group. Further,
the chemical composition of the isolated elicited cells was determined. Total proteins, sugars, lipids and nucleic acids were
significantly low in the cells isolated from protein-deficient animals, though the cell size was not affected. However, cholesterol:
phospholipid molar ratios were distinctly higher than that in control and increased progressively in the 3 and 8 % protein-fed
animals. The implications of these structural changes in macrophages on their functional capability are discussed |
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Keywords: | Rat protein-deficiency growth macrophages proximate composition |
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