Spectroscopic and potentiometric evidence for the stabilization of a bent structure of octapeptides by Cu(II) ions |
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| Authors: | Michel Bataille Leslie D Pettit Ian Steel Henryk Kozlowski Tomasz Tatarowski |
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| Institution: | Laboratoire de Chimie Biologique, L. A. No.217, Universite des Sciences et Techniques de Lille, France;School of Chemistry, University of Leeds, U.K.;Institute of Chemistry, University of Wroclaw, Poland |
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| Abstract: | Syntheses and the results of a potentiometric and spectrophotometric study at 25°C and an ionic strength of 0.10 mol dm?3 (KNO3) of the H + and Cu2+ complexes of two pairs of tetra- and octapeptides are reported. The peptides, Gly-Gly-Pro-Gly and (Gly-Gly-Pro-Gly)2, and Gly-Gly-Pro-Lys and (Gly-Gly-Pro-Lys)2, are models for the biologically active octapeptide with antitumor activity, dog tuftsinyltuftsin. The results clearly demonstrate participation of the ?-NH2 group of -Lys- in metal ion coordination from below pH 6 and, with the octapeptides at high pH, suggest the presence of a bent conformation with a large chelate ring spanning the two ends of the peptide chain. |
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| Keywords: | Address reprint requests to: Dr H Kozlowski Institute of Chemistry University of Wroclaw 14 Joliot-Curie 50-383 Wroclaw Poland |
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