Dynamic localisation of Ran GTPase during the cell cycle |
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| Authors: | James RA Hutchins William J Moore and Paul R Clarke |
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| Institution: | (1) Biomedical Research Institute, College of Medicine, Dentistry and Nursing, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK;(2) Research Institute of Molecular Pathology (IMP), Dr. Bohr-Gasse 7, A-1030 Vienna, Austria;(3) Division of Gene Regulation and Expression, Wellcome Trust Biocentre, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK |
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| Abstract: | Background Ran GTPase has multiple functions during the cell division cycle, including nucleocytoplasmic transport, mitotic spindle assembly
and nuclear envelope formation. The activity of Ran is determined by both its guanine nucleotide-bound state and its subcellular
localization. |
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